Can we put the brakes on cancers’ ability to metastasize? In episode 33, John Lewis from the University of Alberta talks with us about his research into inhibiting cancer cell movement and metastasis through genomic targets. His open-access article “Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis” was published with multiple co-authors in the June 14, 2018 issue of journal Nature Communications.



Websites and other resources


Press coverage

Folio | EurekaAlert | MedicalPress | ScienceDaily | eCancer | Med India | TechnologyNetworks | University of Alberta


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Hosts / Producers

Doug Leigh & Ryan Watkins

How to Cite

Leigh, D., Watkins, R., & Lewis, J. D.. (2018, October 2). Parsing Science – Halting Cancer’s Spread. figshare.


What’s The Angle? by Shane Ivers


John Lewis: The premise of the study was that if we really wanted to learn about how to block metastasis, we really had to do it in a living system.

Ryan Watkins: This is parsing science. The unpublished stories behind the world’s most compelling science as told by the researchers themselves. I’m Ryan Watkins…

Doug Leigh: And I’m Doug Leigh. Over 380,000 deaths are predicted to occur this year in the United States and Canada due to cancers. In more than one million Americans as well as over a hundred thousand Canadians are estimated to be diagnosed with some form of cancer in 2018. Today in episode 33 of parsing science, we’re joined by John Lewis from the University of Alberta in Edmonton. He’ll talk with us about his research into the application of molecular tools to almost completely block the spread of any form of cancer in living cells. Here’s John Lewis.

Lewis: Hi there! My name is John Lewis. I am an associate professor at the University of Alberta in the department of oncology, and I hold the chair, Frank and Carla Sojonki chair, in prostate cancer research supported by the Alberta Cancer Foundation. So, I grew up in a small town called Owen Sound, about 20,000 people, and actually I thought I might become an engineer, so very very interested in new technologies and tools, and became very interested early on in computer programming and things like that. So, I started my education at the University of Western Ontario in London Ontario Canada and studied genetics. But, at the time, I wasn’t sure what career I wanted to enter in. So, I actually took a job, believe it or not, as an income tax consultant and worked for four years doing income tax and corporate income tax and audits and all that. So, I learned a lot about business and I think that’s informed me a lot and sort of what I’m doing now, but realized that I didn’t want a career in bookkeeping. So, I moved out west and started my PhD in the Department of Biochemistry microbiology at the University of Victoria. And the whole time I was doing my PhD, I was sort of searching for how I was gonna use this amazing knowledge. Rather unfortunately, my fiance at the time her father came down with kidney cancer have metastasized to his liver, and so it was, you know, it was at a fairly late stage, and you know, while I was doing these amazing techniques in the laboratory, you know, we had sort of state-of-the-art computers and these amazing analytical techniques, you know, the clinical trials that were offered to him at this sort of late stage were pretty shocking to me. So, at the time there was a clinical trial for, believe it or not, the thalidomide and of course it didn’t have much activity. The other one there was a clinical trial in interleukin-2 which can create some really really horrible side effects, and also didn’t have any effect in his cancer. So, at the time, I was motivated and sort of by the low technology of the clinic to try to apply some of the stuff I learned in my PhD toward cancer. And so, pretty much ever since then I’ve been working on cancer.

Watkins: As John explains, cancer is not one disease but rather a collection of diseases that are deeply complex and far from fully understood. We began our conversation by asking him how it is that cancers can develop and through metastasis spread.
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